Children carrying specific effect alleles (rs7508679, rs10420008, rs11883325, rs4804416) showed greater waist circumference reduction during the intervention compared to those without these alleles, although the benefits diminished over the long term.
Phentermine-topiramate significantly reduced BMI and weight in children and adolescents, with a notable increase in the proportion of participants achieving a BMI reduction of ≥5%.
HIIT significantly improved cardiorespiratory fitness indicators (VO2 max, SBP, DBP, HR) and metabolic risk indicators (TC, HDL-C) for cardiovascular disease, although it did not significantly affect body shape indicators (BMI, BF%, WC).
Improved health outcomes and quality of life for minority children can be achieved through sustained engagement in weight management programs.
Both GLP-1RAs and SGLT-2is led to significant weight loss (at least 5%), improved glycemic control, and reduced blood pressure, with semaglutide 2.4mg showing the most significant effects in these areas.
The study found that for children in the top quintile of genetic risk, changing parental feeding practices to those of children with lower genetic risk could lead to a reduction in BMI by 0.81 kg/m at age 12. This suggests that parental interventions can significantly impact childhood obesity risk.
The meta-analysis found that orlistat treatment resulted in a statistically significant reduction in BMI by 0.72 kg/m² compared to placebo. Additionally, longer treatment duration was associated with greater reductions in BMI.
Increased serum levels of IL-10, improved physical fitness, and potential reduction in obesity-related health risks in children and adolescents.
Bariatric surgery significantly lowers the odds of Major Adverse Cardiovascular Events (MACE) in obese patients with CVDs, with an odds ratio of 0.49 compared to non-surgical controls.
Understanding the relationship between ACEs and health outcomes can inform targeted interventions to reduce early sexual initiation and improve weight status among affected girls.
Carriers of loss of function mutations had significantly higher body weight (mean difference of 17.76kg), BMI (4.84kg/m), and fat mass (14.78kg) at age 18 compared to non-carriers. The study suggests that up to 200,000 people in the UK may carry such mutations, indicating a substantial public health impact.
The use of HFNO showed a higher delta EELI at 1 hour compared to conventional oxygen therapy, suggesting potential benefits in respiratory mechanics post-surgery.
Improved accuracy in maternal weight perception may lead to healthier feeding practices, potentially reducing the risk of childhood obesity and related health issues.
Higher levels of circulating apoM and adiponectin were associated with improved insulin sensitivity and lower levels of inflammation and metabolic dysfunction. Sleeve gastrectomy led to significant improvements in insulin sensitivity, particularly linked to changes in apoM levels.
Increased physical activity, reduced screen time, and improved sleep duration among children and adolescents.
The study observed a significant reduction in circulating macrophage scavenger receptor type-I (MSR1) levels, indicating a potential positive effect of exercise on this novel biomarker, although it did not mediate changes in brain health outcomes.
Successful management of OSA was associated with a significant reduction in systolic blood pressure (SBP) in hypertensive patients. Specifically, CPAP treatment resulted in a greater improvement in SBP z-score percentile compared to surgical treatment, indicating a more pronounced positive effect on hypertension.